Lee:OMICS

총 40건 (필터 적용됨)

Research Article

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee
Advanced Materials [2025]

링크

Research Article

SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease

Mridula Bhalla, Jinhyeong Joo, Daeun Kim, Jeong Im Shin, Yongmin Mason Park, Yeon Ha Ju, Uiyeol Park, Seonguk Yoo, Seung Jae Hyeon, Hyunbeom Lee, Junghee Lee, Hoon Ryu, C Justin Lee
Molecular Neurodegeneration [2025]

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Research Article

Simple and robust high-throughput serum proteomics workflow with low-microflow LC–MS/MS

Yoondam Seo, Inseon Kang, Hyeon-Jeong Lee, Jiin Hwang, Soo Heon Kwak, Min-Kyu Oh, Hyunbeom Lee, Hophil Min
Analytical and Bioanalytical Chemistry [2024]

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Research Article

Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease

Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim, Uiyeol Park, Jiyeon Chu, Mridula Bhalla, Seung-Hye Choi, Ali Yousefian-Jazi, Sojung Kim, Seung Jae Hyeon, Seungchan Kim, Yeonseo Kim, Yeon Ha Ju, Seung Eun Lee, Hyunbeom Lee, Kyungeun Lee, Soo-Jin Oh, Eun Mi
Molecular Neurodegeneration [2024]

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Research Article

Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma

Byung-Sun Park, Heeju Jeon, Yeonseo Kim, Haejin Kwon, Ga-Eun Choi, Sung-Gil Chi, Hyun-Mee Park, Hyunbeom Lee, Tackhoon Kim
Molecular cancer [2024]

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Research Article

Metabolomics and miRNA profiling reveals feature of gallbladder cancer-derived biliary extracellular vesicles

Mingyu Kong, Sanjita Paudel, Na Eun Yoon, Byung Hwa Jung, Myounghoi Kim, Tae Hun Kim, Jaemin Jeong, Dongho Choi, Hyunbeom Lee
Biochemical and Biophysical Research Communications [2024]

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Research Article

Antioxidant and Inhibitory Activities of Filipendula glaberrima Leaf Constituents against HMG-CoA Reductase and Macrophage Foam Cell Formation

You Bin Cho, Hyunbeom Lee, Hui-Jeon Jeon, Jae Yeol Lee, Hyoung Ja Kim
Molecules [2024]

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Research Article

Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia

Ji Eun Shin, Soo-Hyun Kim, Mingyu Kong, Hwa-Ryeon Kim, Sungmin Yoon, Kyung-Mi Kee, Jung Ah Kim, Dong Hyeon Kim, So Yeon Park, Jae Hyung Park, Hongtae Kim, Kyoung Tai No, Han-Woong Lee, Heon Yung Gee, Seunghee Hong, Kun-Liang Guan, Jae-Seok Roe, Hyunbeom L
Molecular cancer [2023]

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Research Article

Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants

Elliot H Lee, Jung-eun Park, Lizaveta Gotina, Young-Eun Han, Ambily Nath Indu Viswanath, Seonguk Yoo, Bongjin Moon, Jin-Young Hwang, Woo Kyu Park, Yoonjeong Cho, Chiman Song, Sun-Joon Min, Eun Mi Hwang, Hyunbeom Lee, Ae Nim Pae, Eun Joo Roh, Soo-Jin Oh
Biomedicine & Pharmacotherapy [2023]

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Research Article

Anti-inflammatory effect and metabolic mechanism of BS012, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts, on atopic dermatitis in vivo and in vitro

Gakyung Lee, Jinyoung Park, Hyunbeom Lee, Kyeong Seok Kim, Jae Hyeon Park, So Young Kyung, Hyung Sik Kim, Hyun Ok Yang, Byung Hwa Jung
Phytomedicine [2023]

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Research Article

Visualizing reactive astrocyte-neuron interaction in Alzheimer’s disease using 11C-acetate and 18F-FDG

Min-Ho Nam, Hae Young Ko, Dongwoo Kim, Sangwon Lee, Yongmin Mason Park, Seung Jae Hyeon, Woojin Won, Jee-In Chung, Seon Yoo Kim, Han Hee Jo, Kyeong Taek Oh, Young-Eun Han, Gwan-Ho Lee, Yeon Ha Ju, Hyowon Lee, Hyunjin Kim, Jaejun Heo, Mridula Bhalla, Ki Ju
Brain [2023]

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Research Article

Metabolites identification for major active components of Agastache rugosa in rat by UPLC-Orbitap-MS: Comparison of the difference between metabolism as a single component and as a component in a multi-component extract

Ah-kyung Jang , Md Mamunur Rashid, Gakyung Lee a, Doo-Young Kim, Hyung Won Ryu, Sei-Ryang Oh, Jinyoung Park, Hyunbeom Lee , Jongki Hong, Byung Hwa Jung
Journal of Pharmaceutical and Biomedical Analysis [2022]

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Research Article

Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease

Yeon Ha Ju, Mridula Bhalla, Seung Jae Hyeon, Ju Eun Oh, Seonguk Yoo, Uikyu Chae, Jea Kwon, Wuhyun Koh, Jiwoon Lim, Yongmin Mason Park, Junghee Lee, Il-Joo Cho, Hyunbeom Lee, Hoon Ryu, C Justin Lee
Cell Metabolism [2022]

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Research Article

Inhibiting peripheral and central MAO-B ameliorates joint inflammation and cognitive impairment in rheumatoid arthritis

Woojin Won, Hyun-Ji Choi, Ji-Young Yoo, Daeun Kim, Tai Young Kim, YeonHa Ju, Ki Duk Park, Hyunbeom Lee, Sang Youn Jung, C Justin Lee
Experimental & Molecular Medicine [2022]

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Research Article

LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming

Kelvin Pieknell, Yanuar Alan Sulistio, Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Mi-Yoon Chang, Ji-Yun Ko, Jong Wook Chang, Min-Jeong Kim, Man Ryul Lee, Sang A Lee, Hyunbeom Lee, Gakyung Lee, Byung Hwa Jung, Hyunbum Park, Geun-ho Kim, Doory Kim, Ga
Cell Death & Differentiation [2022]

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Research Article

USP14 regulates cancer cell growth in a fatty acid synthase-independent manner

Ji Su Yang, Naeun Yoon, Mingyu Kong, Byung Hwa Jung, Hyunbeom Lee, Jinyoung Park
International Journal of Molecular Sciences [2021]

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Research Article

Comparative metabolomics and lipidomics study to evaluate the metabolic differences between first- and second-generation mammalian or mechanistic target of rapamycin inhibitors

Md Mamunur Rashid, Hyunbeom Lee, Jinyoung Park, Byung Hwa Jung
Biomedical Chromatography [2021]

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Research Article

Aster glehni F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase

Hyunbeom Lee, Hyoung Ja Kim, Hyungi Chae, Na Eun Yoon, Byung Hwa Jung
Plants [2021]

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Research Article

A metabolomics investigation of the metabolic changes of raji b lymphoma cells undergoing apoptosis induced by zinc ions

Naeun Yoon, Hyunbeom Lee, Geonhee Lee, Eun Hye Kim, Seong Hwan Kim, Jeong-O Lee, Yunseon Song, Jinyoung Park, So-Dam Kim, Yeojin Kim, Byung Hwa Jung
Metabolites [2021]

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Research Article

Short-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

Gakyung Lee, Young Suk Park, Chamlee Cho, Hyunbeom Lee, Jinyoung Park, Do Joong Park, Joo Ho Lee, Hyuk-Joon Lee, Tae Kyung Ha, Yong-Jin Kim, Seung-Wan Ryu, Sang-Moon Han, Moon-Won Yoo, Sungsoo Park, Sang-Uk Han, Yoonseok Heo, Byung Hwa Jung
Metabolomics [2021]

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Research Article

Visualization of reactive astrocytes in living brain of Alzheimer’s disease patient

Min-Ho Nam, Hae Young Ko, Sangwon Lee, Yongmin Mason Park, Seung Jae Hyeon, Woojin Won, Seon Yoo Kim, Han Hee Jo, Jee-In Chung, Young-Eun Han, Gwan-Ho Lee, Yeonha Ju, Thor D Stein, Mingyu Kong, Hyunbeom Lee, Seung Eun Lee, Soo-Jin Oh, Joong-Hyun Chun, Ki
BioRxiv [2021]

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Research Article

Astrocytes control sensory acuity via tonic inhibition in the thalamus

Hankyul Kwak, Wuhyun Koh, Sangwoo Kim, Kiyeong Song, Jeong-Im Shin, Jung Moo Lee, Elliot H Lee, Jin Young Bae, Go Eun Ha, Ju-Eun Oh, Yongmin Mason Park, Sunpil Kim, Jiesi Feng, Seung Eun Lee, Ji Won Choi, Ki Hun Kim, Yoo Sung Kim, Junsung Woo, Dongsu Lee,
Neuron [2020]

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Research Article

Deciphering fatty acid synthase inhibition-triggered metabolic flexibility in prostate cancer cells through untargeted metabolomics

Ju Eun Oh, Byung Hwa Jung, Jinyoung Park, Soosung Kang, Hyunbeom Lee
Cells [2020]

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Research Article

Evaluation of the antitumor effects of PP242 in a colon cancer xenograft mouse model using comprehensive metabolomics and lipidomics

Md Mamunur Rashid, Hyunbeom Lee, Byung Hwa Jung
Scientific Reports [2020]

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Research Article

Analysis of plasma metabolic profiling and evaluation of the effect of the intake of Angelica keiskei using metabolomics and lipidomics

Hyun-A Oh, Hyunbeom Lee, Soo-yeon Park, Yeni Lim, Oran Kwon, Ji Yeon Kim, Donghak Kim, Byung Hwa Jung
Journal of Ethnopharmacology [2019]

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Research Article

Identification of interactions between multiple components in Socheongryong‐tang using a plant profiling approach

Hyun‐A Oh, Hyunbeom Lee, Keon Wook Kang, Ji Hye Im, Donghak Kim, Hyun Ok Yang, Byung Hwa Jung
Biomedical Chromatography [2019]

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Research Article

Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics

Hyunbeom Lee, Jong Min Choi, Joo-Youn Cho, Tae-Eun Kim, Hwa Jeong Lee, Byung Hwa Jung
Chemistry and physics of lipids [2018]

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Research Article

Metabolite identification and pharmacokinetic profiling of PP242, an ATP-competitive inhibitor of mTOR using ultra high-performance liquid chromatography and mass spectrometry

Md Mamunur Rashid, Hyunbeom Lee, Byung Hwa Jung
Journal of Chromatography B [2018]

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Research Article

Metabolite identification of AZD8055 in Sprague-Dawley rats after a single oral administration using ultra-performance liquid chromatography and mass spectrometry

Md Mamunur Rashid, Hyun-A Oh, Hyunbeom Lee, Byung Hwa Jung
Journal of Pharmaceutical and Biomedical Analysis [2017]

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Research Article

Development of GC-MS based cytochrome P450 assay for the investigation of multi-herb interaction

Hyun-A Oh a b , Hyunbeom Lee a , Donghak Kim b, Byung Hwa Jung a c
Analytical Biochemistry [2017]

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Research Article

Metabolomics study of cancer targeting small molecule kinase inhibitors in cell culture

Hyunbeom Lee, Na Eun Yoon, Byung Hwa Jung
Drug Metabolism and Pharmacokinetics [2017]

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Research Article

Quantitative profiling of bile acids in rat bile using ultrahigh-performance liquid chromatography–orbitrap mass spectrometry: Alteration of the bile acid composition with aging

Gakyung Lee a b , Hyunbeom Lee a , Jongki Hong b, Soo Hyun Lee d , Byung Hwa Jung a c
Journal of Chromatography B [2016]

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Research Article

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

Hyunbeom Lee†Hoang V. Le†Rui Wu§Emma Doud‡Ruslan Sanishvili∥John F. Kellie‡Phillip D. Compton‡Boobalan Pachaiyappan†Dali Liu§Neil L. Kelleher‡Richard B. Silverman
Get e-Alerts ACS Chemical Biology [2015]

링크

Research Article

Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase

Ehud Zigmond†Ami Ben Ya’acov†Hyunbeom Lee∥Yoav Lichtenstein†Zvi Shalev†Yoav Smith‡Lidya Zolotarov†Ehud Ziv§Rony Kalman§Hoang V. Le∥Hejun Lu∥Richard B. Silverman*∥Yaron Ilan*†
ACS Medicinal Chemistry Letters [2015]

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Research Article

Synthesis and evaluation of a new bifunctional NETA chelate for molecular targeted radiotherapy using90Y or177Lu

Chi Soo Kang a , Yunwei Chen a , Hyunbeom Lee a , Dijie Liu c , Xiang Sun a , Junghun Kweon a , Michael R. Lewis b c, Hyun-Soon Chong a
Nuclear Medicine and Biology [2015]

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Review Article

Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs

Hyunbeom Lee, Jose I. Juncosa, Richard B. Silverman
Medicinal Research Reviews [2014]

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Research Article

Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)

Hyunbeom Lee†Emma H. Doud†‡Rui Wu§Ruslan Sanishvili∥Jose I. Juncosa†Dali Liu§Neil L. Kelleher†‡Richard B. Silverman*†‡
Journal of the American Chemical Society [2014]

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Research Article

Two continuous coupled assays for ornithine-δ-aminotransferase

Jose I. Juncosa a 1 , Hyunbeom Lee a 1 , Richard B. Silverman a b
Analytical Biochemistry [2013]

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Research Article

(1S, 3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction

Yue Pan†Madina R. Gerasimov‡Trine Kvist§Petrine Wellendorph§Karsten K. Madsen∥Elena Pera⊥Hyunbeom Lee†Arne Schousboe∥Mary Chebib⊥Hans Bräuner-Osborne§Cheryl M. Craft#Jonathan D. Brodie∞Wynne K. Schiffer‡Stephen L. Dewey‡Steven R. Miller×Richard B. Silverm
Journal of Medicinal Chemistry [2011]

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Research Article

A highly effective bifunctional ligand for radioimmunotherapy applications

Hyun-Soon Chong *, Hyun A. Song , Chi Soo Kang , Thien Le , Xiang Sun , Mamta Dadwal , Hyunbeom Lee , Xiaoli Lan , Yunwei Chen and Anzhi Dai
Chemical Communications [2011]

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Journal Papers

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease

Simple and robust high-throughput serum proteomics workflow with low-microflow LC–MS/MS

Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease

Polyamine and EIF5A hypusination downstream of c-Myc confers targeted therapy resistance in BRAF mutant melanoma

Metabolomics and miRNA profiling reveals feature of gallbladder cancer-derived biliary extracellular vesicles

Antioxidant and Inhibitory Activities of Filipendula glaberrima Leaf Constituents against HMG-CoA Reductase and Macrophage Foam Cell Formation

Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia

Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants

Anti-inflammatory effect and metabolic mechanism of BS012, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts, on atopic dermatitis in vivo and in vitro

Visualizing reactive astrocyte-neuron interaction in Alzheimer’s disease using 11C-acetate and 18F-FDG

Metabolites identification for major active components of Agastache rugosa in rat by UPLC-Orbitap-MS: Comparison of the difference between metabolism as a single component and as a component in a multi-component extract

Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease

Inhibiting peripheral and central MAO-B ameliorates joint inflammation and cognitive impairment in rheumatoid arthritis

LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming

USP14 regulates cancer cell growth in a fatty acid synthase-independent manner

Comparative metabolomics and lipidomics study to evaluate the metabolic differences between first- and second-generation mammalian or mechanistic target of rapamycin inhibitors

Aster glehni F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase

A metabolomics investigation of the metabolic changes of raji b lymphoma cells undergoing apoptosis induced by zinc ions

Short-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass

Visualization of reactive astrocytes in living brain of Alzheimer’s disease patient

Astrocytes control sensory acuity via tonic inhibition in the thalamus

Deciphering fatty acid synthase inhibition-triggered metabolic flexibility in prostate cancer cells through untargeted metabolomics

Evaluation of the antitumor effects of PP242 in a colon cancer xenograft mouse model using comprehensive metabolomics and lipidomics

Analysis of plasma metabolic profiling and evaluation of the effect of the intake of Angelica keiskei using metabolomics and lipidomics

Identification of interactions between multiple components in Socheongryong‐tang using a plant profiling approach

Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia patients: An integration of metabolomics and lipidomics

Metabolite identification and pharmacokinetic profiling of PP242, an ATP-competitive inhibitor of mTOR using ultra high-performance liquid chromatography and mass spectrometry

Metabolite identification of AZD8055 in Sprague-Dawley rats after a single oral administration using ultra-performance liquid chromatography and mass spectrometry

Development of GC-MS based cytochrome P450 assay for the investigation of multi-herb interaction

Metabolomics study of cancer targeting small molecule kinase inhibitors in cell culture

Quantitative profiling of bile acids in rat bile using ultrahigh-performance liquid chromatography–orbitrap mass spectrometry: Alteration of the bile acid composition with aging

Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid

Suppression of Hepatocellular Carcinoma by Inhibition of Overexpressed Ornithine Aminotransferase

Synthesis and evaluation of a new bifunctional NETA chelate for molecular targeted radiotherapy using90Y or177Lu

Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs

Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)

Two continuous coupled assays for ornithine-δ-aminotransferase

(1S, 3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction

A highly effective bifunctional ligand for radioimmunotherapy applications